Serum S100B protein concentrations in SGA/FGR newborns

Objectives: Fetal growth restriction is associated with chronic fetal hypoxia, poor perinatal outcome and increased mortality. There are no reliable methods to detect cell damage in the central nervous system (CNS) these patients. The findings of an acidic calcium-binding protein (S100B) concentration biological fluids infants after brain injury have supported use S100B as a biochemical marker CNS damage. purpose study was assess blood concentrations small for gestational age (SGA) appropriate (AGA) newborns evaluate usefulness early detection hypoxia. Material methods: investigation carried out between November 2011 April 2014. Serum level assessed cord collected from birth. Medical records mothers neonates studied were reviewed pregnancy induced hypertension (PIH), preeclampsia, maternal smoking during abnormalities umbilical artery (UA) Doppler ultrasound examination. Results: 88 SGA 80 AGA neonates. median value group significantly higher than controls (p < 0.001). Cord serum prenatal normal UA (n = 32) did not differ that abnormal 25) 0.74), but Conclusions: Elevated levels may be helpful detecting at risk postnatal neurologic disturbances stage.